PRKAA1 Antibody is a Rabbit Polyclonal antibody against PRKAA1. The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Target	5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 381-520 of human AMPKα1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13131 (UniProt, ExPASy)
UniProt Secondary AC	A8MTQ6, B2R7E1, O00286, Q5D0E1, Q86VS1, Q9UNQ4
UniProt Entry Name	AAPK1_HUMAN
Gene Symbol	PRKAA1
GeneID	5562
NCBI Accession	NP_006242.5
KEGG	hsa:5562
String	9606.ENSP00000346148
Molecular Weight	Calculated MW: 64 kDa Observed MW: 64 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1)