The protein belongs to the ser/thr protein kinase family.It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK).AMPK is a cellular energy sensor conserved in all eukaryotic cells.The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio.AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation.It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Target	5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1)
Clonality	Monoclonal
Reactivity	Human, Monkey, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human PRKAA1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	5562
Molecular Weight	64 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1)