產(chǎn)品詳情
簡(jiǎn)單介紹:
26S Proteasome Regulatory Subunit 8 (PSMC5) Antibody (FITC)
詳情介紹:
26S Proteasome Regulatory Subunit 8 (PSMC5) Antibody (FITC) is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 8 (PSMC5) conjugated to FITC. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
Research Articles on 26S Proteasome Regulatory Subunit 8 (PSMC5)
Target | 26S Proteasome Regulatory Subunit 8 (PSMC5) |
Clonality | Polyclonal |
Reactivity | Human |
Host | Rabbit |
Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
Conjugation | FITC |
Excitation/Emission | 499/515 |
Laser Line | 488 |
Immunogen | Recombinant Human 26S protease regulatory subunit 8 protein (253-324AA). |
Isotype | IgG |
Form | Liquid |
Purity | > 95% |
Purification | Purified by Protein G. |
Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC | P62195 (UniProt, ExPASy) |
UniProt Secondary AC | A8K3Z3, A8K763, O35051, O43208, P47210, P52915, P52916 |
UniProt Entry Name | PRS8_HUMAN |
Gene Symbol | PSMC5 |
GeneID | 5705 |
OMIM | 601681 |
NCBI Accession | NP_001186092.1 NM_001199163.1 NP_002796.4 NM_002805.5 |
KEGG | hsa:5705 |
String | 9606.ENSP00000310572 |
Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |
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