The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.

Target	26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 276-304 amino acids from the Central region of human PSMD12.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00232 (UniProt, ExPASy)
UniProt Secondary AC	A6NP15, Q53HA2, Q6P053
UniProt Entry Name	PSD12_HUMAN
Gene Symbol	PSMD12
GeneID	5718
OMIM	604450
NCBI Accession	NP_001303270.1 NM_001316341.1 NP_002807.1 NM_002816.4
HGNC	9557
KEGG	hsa:5718
Ensembl	ENSG00000197170
String	9606.ENSP00000348442
Molecular Weight	Calculated MW: 52.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow PSMD12.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12)