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產(chǎn)品詳情
  • 產(chǎn)品名稱:4-Aminobutyrate Aminotransferase (ABAT) Antibody

  • 產(chǎn)品型號:abx004049
  • 產(chǎn)品廠商:abbexa
  • 產(chǎn)品文檔:
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簡單介紹:
4-Aminobutyrate Aminotransferase (ABAT) Antibody
詳情介紹:
ABAT Antibody is a Rabbit Polyclonal antibody against ABAT. 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Target 4-Aminobutyrate Aminotransferase (ABAT)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 29-300 of human GABA transaminase (ABAT).
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P80404 (UniProt, ExPASy)
UniProt Secondary AC A8K386, Q16260, Q8N5W2, Q96BG2, Q99800
UniProt Entry Name GABT_HUMAN
Gene Symbol ABAT
GeneID 18
OMIM 137150
NCBI Accession NP_001120920.1
HGNC 23
KEGG hsa:18
Ensembl ENSG00000183044
String 9606.ENSP00000379845
Molecular Weight Calculated MW: 56 kDa
Observed MW: 50 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on 4-Aminobutyrate Aminotransferase (ABAT)
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