Polyclonal Antibody to 26S Proteasome Regulatory Subunit 6B (PSMC4). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target	26S Proteasome Regulatory Subunit 6B (PSMC4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 0.5-2 μg/ml, IHC: 5-20 μg/ml, IF/ICC: 5-20 μg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	PSMC4 (Met1-Lys418)
Form	Liquid
Purification	Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43687 (UniProt, ExPASy)
UniProt Secondary AC	Q96FV5, Q9UBM3, Q9UEX4
UniProt Entry Name	PRS6B_HUMAN
Gene Symbol	PSMC4
GeneID	5704
OMIM	602707
NCBI Accession	NP_006494.1 NM_006503.3 NP_694546.1 NM_153001.2
HGNC	9551
KEGG	mmu:15372
Ensembl	ENSG00000013275
String	9606.ENSP00000157812
Buffer	0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability	Shipped within 5-7 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)