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產(chǎn)品詳情
  • 產(chǎn)品名稱:26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody

  • 產(chǎn)品型號(hào):abx103500
  • 產(chǎn)品廠商:abbexa
  • 產(chǎn)品文檔:
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簡單介紹:
26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody
詳情介紹:
Polyclonal Antibody to 26S Proteasome Regulatory Subunit 6B (PSMC4). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target 26S Proteasome Regulatory Subunit 6B (PSMC4)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 0.5-2 μg/ml, IHC: 5-20 μg/ml, IF/ICC: 5-20 μg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen PSMC4 (Met1-Lys418)
Form Liquid
Purification Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P43687 (UniProt, ExPASy)
UniProt Secondary AC Q96FV5, Q9UBM3, Q9UEX4
UniProt Entry Name PRS6B_HUMAN
Gene Symbol PSMC4
GeneID 5704
OMIM 602707
NCBI Accession NP_006494.1 NM_006503.3 NP_694546.1 NM_153001.2
HGNC 9551
KEGG mmu:15372
Ensembl ENSG00000013275
String 9606.ENSP00000157812
Buffer 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability Shipped within 5-7 working days.
Note This product is for research use only.
Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)
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