Polyclonal Antibody to 26S Proteasome Regulatory Subunit 10B (PSMC6). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

Target	26S Proteasome Regulatory Subunit 10B (PSMC6)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 0.5-2 μg/ml, IHC: 5-20 μg/ml, IF/ICC: 5-20 μg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	PSMC6 (Ala2-Val403)
Form	Liquid
Purification	Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P62333 (UniProt, ExPASy)
UniProt Secondary AC	B2R975, P49719, Q6IBU3, Q92529
UniProt Entry Name	PRS10_HUMAN
Gene Symbol	PSMC6
GeneID	5706
OMIM	602708
HGNC	9553
KEGG	hsa:5706
Ensembl	ENSG00000100519
String	9606.ENSP00000401802
Buffer	0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability	Shipped within 5-7 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 10B (PSMC6)