PSMD8 Antibody is a Rabbit Polyclonal against PSMD8. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.

Target	26S Proteasome Non-ATPase Regulatory Subunit 8 (PSMD8)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Fusion protein of human PSMD8.
Isotype	IgG
Form	Liquid
Purification	Antigen Affinity Chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48556 (UniProt, ExPASy)
UniProt Secondary AC	B4DX18, Q6P1L7
UniProt Entry Name	PSMD8_HUMAN
Gene Symbol	PSMD8
GeneID	5714
KEGG	hsa:5714
String	9606.ENSP00000215071
Buffer	PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 8 (PSMD8)