DHCR24 is a flavin adenine dinucleotide (FAD) dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Target	24-Dehydrocholesterol Reductase (DHCR24)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 57-87 amino acids from the N-terminal region of human DHCR24.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15392 (UniProt, ExPASy)
UniProt Secondary AC	B7Z817, D3DQ51, Q9HBA8
UniProt Entry Name	DHC24_HUMAN
KEGG	hsa:1718
String	9606.ENSP00000360316
Molecular Weight	Calculated MW: 60.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey DHCR24.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 24-Dehydrocholesterol Reductase (DHCR24)